
Data + AI
The key to AI
is understanding where and when it will be disruptive
.
Our team helps brilliant founders build companies that maximize the potential of AI to reshape the world and solve our biggest problems.
Why Data and AI
Artificial intelligence and the underlying data infrastructure that powers it are moving at light speed.
The number of models, infrastructure solutions, and enabled and agentic applications are growing exponentially, and enterprise adoption of these technologies is increasingly complicated and nuanced.
At .406, our team leverages our singular focus, active buyer network, and tech trend understanding to accelerate the next big deep tech ideas and solutions. We work with Fortune 100 buyers to help them identify next-trend technologies and solutions to their most pressing problems. This work serves as the basis of our theses and drives the make-up of our portfolio.
“.406 Ventures brings deep industry experience in guiding companies through every stage. Their focus on long-term partnership is incredibly valuable as they engage with founders at the earliest stages to architect sustainable, high-performance growth strategies. The .406 team has continuously proven themselves as true value-creation partners across every one of our critical business milestones.”

Manish Sood
Founder and CEO, Reltio
“As we continuously evolve our platform, .406 Ventures has been instrumental in not only validating our architecture but continually connecting us with the latest companies innovating in this space. As we started to introduce GenAI in our stack, Graham Brooks has been a crucial advisor on how best to leverage the technology and uniquely position us in the marketplace.”

Navdeep Alam
Chief Technology Officer, Abacus
Where We Invest
- AI Infrastructure
- Data Infrastructure
- Vertical AI Applications
The .406 Edge
We know data and AI.
We’ve been investing in AI and the data behind it for more than 15 years and understand the challenges that you, as entrepreneurs, will face.
We understand and have validated the need you are addressing before our first meeting.
From identifying enterprise buyers looking for your solution to pinpointing what makes you unique in the ecosystem and the core risks you’re working on, our thesis-based approach enables us to jump right into the meat of your innovation and why it positions you to be a category winner.
We are opinionated investors.
We have specific theses driving our deep industry dives, backed up by validated need from Fortune 100 buyers so we can get you the answers you need to keep moving.
Our networks run deep.
Our extensive network of Fortune 100 buyers look to us to help them stay on top of the most innovative new technologies. We know what problems they are going to be looking for start-ups to solve next year and the year after.
We’re tech-first so we can be partnership-forward.
We are shameless geeks. Our technical expertise enables us to deeply partner with you to accelerate your go-to-market and invest with confidence in early, pre-product opportunities.
We understand how to build great companies from novel research.
Whether developed in a university lab, on the back of a napkin, or in your unused garage, we have the playbook to bring true AI innovation to market. More than 40% of our investments are born from deep research out of academia and labs, and we understand the unique challenges to research-driven entrepreneurship and can help academic founders become business builders and successful serial entrepreneurs.
We’re ground-up builders.
We are go-to-market experts and can help technical founders develop and test messaging, strategy, and pricing and bring a network to help you leverage those fundamentals to attract your first enterprise customers.
Sector Intersections
Data + AI x Healthcare
Data infrastructure is essential to preventative care, patient engagement, timely care delivery, and measuring value. Paired with automation and AI, it powers smarter, more efficient healthcare.
Data + AI x Cybersecurity
AI tech capabilities are advancing exponentially, creating new attack surfaces as well as powerful new tools for adversaries. We are investing in cutting edge companies that protect AI as well as those that use advanced AI to combat cyber threats across the stack.
Companies
Get to know our data + AI companies
Abacus Insights

- Healthcare
- Data + AI
Abacus Insights provides a centralized, trusted data, insights, and AI platform for the healthcare ecosystem.
Adtuitive

- Data + AI
Adtuitive leveraged AI to automatically generate ads and contextually match them to online content. Acquired by Etsy.
Bedrock Data

- Data + AI
Bedrock was a data management system that helps users collect and aggregate data to increase workplace productivity. Acquired by Formstack.
Bobsled

- Data + AI
Bobsled is a data-sharing platform that allows users to make their data available in any cloud or data platform.
Business Intelligence Advisors

- Data + AI
Business Intelligence Advisors leverages AI to automate deception detection techniques developed for national security for use in high-stakes commercial settings.
ChaosSearch

- Data + AI
ChaosSearch allows businesses to store, query, and visualize large volumes of log and event data at a significantly reduced cost.
ClosedLoop

- Healthcare
- Data + AI
ClosedLoop offers an end-to-end healthcare data science and AI platform to help healthcare organizations improve clinical and financial outcomes.
CloudHealth Technologies

- Data + AI
CloudHealth provided cloud infrastructure cost and performance management. Acquired by VMware.
Compass

- Data + AI
Compass used advanced data and AI to build a modern real estate platform to make the search and sell experience intelligent and seamless. IPO.
Our Team


About the Council
Exponential knowledge
found here.
Our Executive Council assembles people at the forefront of data and AI to help us assess the biggest problems to solve.