News & Insights
Discover the latest
Stay up to date with the .406 ecosystem of companies and thinkers.
Latest News
May 12, 2026
Scaling Prior Authorization Automation at Texas Health Resources with Humata
exas Health Resources, a ~$6 billion health system operating 29 hospitals across North Texas, was managing mounting write-offs, a relentless cycle of denials, and a revenue cycle team stretched thin by manual authorization workflows.
- Healthcare
May 7, 2026
InStride Health Wins Mental Health Innovation Award in 2026 MedTech Breakthrough Awards Program
InStride Health, the leading provider of specialty mental health care for youth with complex anxiety, OCD, and related disorders, has been named the winner of the Mental Health Innovation Award in the 2026 MedTech Breakthrough Awards program.
- Healthcare
May 7, 2026
InStride Health Sustains Outstanding Clinical Results in Third Annual Outcomes Report; Announces State Expansion Across East Coast
InStride Health, the leader in pediatric mental health for young people with complex anxiety, OCD, and related disorders, today announced findings from its 2026 Annual Clinical Outcomes Report, highlighting significant clinical improvement across a large, real-world patient population as the organization scaled care to more youth and families.
- Healthcare
May 7, 2026
Trilio Launches Trilio Site Recovery to Deliver Storage-Agnostic Disaster Recovery for Red Hat OpenShift Virtualization
The new kernel-based replication solution delivers automated site failover and recovery designed to achieve zero RPO regardless of underlying storage.
- Cybersecurity
- Data + AI
April 23, 2026
Reltio Unlocks the 90% of “Dark” Enterprise Data that Bridges the AI Readiness Gap
Reltio 2026.1 Release Transforms Unstructured Data into Trusted Context; Insurance Customer Achieves 75% Reduction in Manual Document Processing
- Data + AI
April 22, 2026
Trilio and Bigstack Announce Partnership to Deliver Advanced Data Protection in the Asia-Pacific Market
Integrated backup, disaster recovery, and workload mobility now available within Bigstack’s CubeCOS
- Cybersecurity
- Data + AI
April 21, 2026
AristaMD Selected for Inaugural Cohort of Federal CMS ACCESS Model to Reshape Chronic Care Delivery
AristaMD, a technology-enabled clinical services organization addressing specialty care challenges for risk-bearing primary care provider organizations, has been selected to participate in the inaugural cohort of the Centers for Medicare & Medicaid Services ACCESS Model.
- Healthcare
April 21, 2026
The Most Dangerous Word In Healthcare Isn’t ‘Cost’—It’s ‘Appropriate’
Dr. Jeff Wessler (MD MPhil FACC) is a virtual cardiologist, the Founder of Heartbeat Health, and on clinical faculty at Northwell Health.
- Healthcare
forbes.com
April 16, 2026
Telmai and iLink Digital Partner to Bring AI-Driven Data Observability to Enterprises
The rise of agentic AI is exposing a critical gap in enterprise data infrastructure. Autonomous systems execute thousands of decisions per second on data they cannot verify, and when that data is unreliable, the consequences compound at machine speed. Telmai and iLink Digital are addressing this together by combining continuous data observability with enterprise scale implementation expertise, ensuring every AI workload runs on a foundation it can trust.
- Data + AI
Investment Stories
April 22, 2025
In the Zone | Our Investment in NaceAI
"AI should work for enterprises, not the other way around. Our MetaModel shapes AI around your business—task-specific and policy-aligned." — Dos Baha, Founder and CEO of NaceAI
- Data + AI
March 11, 2025
In the Zone | Our Investment in Bluebird Kids Health
“Bluebird Kids Health is a committed, multi-disciplinary team of people that’s changing pediatric care, one child at a time.” – Chris Johnson, CEO of Bluebird Kids
- Healthcare
January 30, 2025
In the Zone | Our Investment in Mindgard
“All software has security risks, and AI is no exception. The challenge is that the way these risks manifest within AI is fundamentally different from other software. Drawing on our 10 years of experience in AI security research, Mindgard was created to tackle this challenge. We’re proud to lead the charge toward creating a safer, more secure future for AI.”– Peter Garraghan, Co-founder and CEO of Mindgard
- Cybersecurity
- Data + AI
May 29, 2024
In the Zone | Our Investment in OncoveryCare
“At OncoveryCare, we believe cancer survivorship is the next frontier in cancer care. And in order to build a radical new approach to this phase of care, we knew we had to bring together a dream team of collaborators and investors who were knowledgeable and passionate about this space—and the team at .406 was the perfect partner.”– Hil Moss, Founder & CEO of OncoveryCare
- Healthcare
February 29, 2024
In the Zone | Our Investment in FamilyWell
“I had difficulty finding support when I experienced postpartum depression and have cared for countless new moms struggling to access mental health care during one of the most vulnerable periods of their lives. My experience, both as a survivor and as a practicing neonatologist, inspired me to start FamilyWell to provide equitable, affordable, and accessible mental healthcare for new mothers.” – Dr. Jessica Gaulton, MD MPH, Founder of FamilyWell
- Healthcare
July 20, 2023
In the Zone | Our Investment Portrait Analytics
“I’ve spent most of my career as a hedge fund analyst, and we are building the tool I always wished I had when I was researching businesses.”– David Plon, Co-Founder and CEO of Portrait Analytics
- Data + AI
April 25, 2023
In the Zone | Our Investment in Bobsled
“Bobsled’s data sharing platform enables data providers, SaaS companies, and data teams to share analytics-ready data products natively into a consumer’s data lake or warehouse, enabling their customers to spend less time on data wrangling and more time generating insights.”– Jake Graham, Co-Founder and CEO of Bobsled
- Data + AI
Podcasts
May 19, 2026
Breaking Health Podcast
Payal Agrawal Divakaran with Sofia Noori: How PTSD Recovery is Possible
- Healthcare
January 20, 2026
Breaking Health Podcast
Payal Agrawal Divakaran with Jess Gaulton: Women’s Mental Healthcare at All Stages
- Healthcare
January 6, 2026
Technoventure
Liam Donohue on Fixing U.S. Healthcare: Why AI Alone Won’t Save It
- Healthcare
November 20, 2025
Expanding Access Podcast
Liam Donohue – Mental Health’s Role in Accelerating Recovery From Workplace Injury
- Healthcare
August 19, 2025
Breaking Health Podcast
Payal Agrawal Divakaran: Medicaid Innovation and Sustainable Ventures
- Healthcare
July 17, 2025
Bloomberg Intelligence: Vanguards of Health Care
Payal Agrawal Divakaran on .406 Ventures’ Early-Stage Strategy
- Healthcare
May 13, 2025
Breaking Health Podcast
Payal Agrawal Divakaran with Jeremy Friese: Solving Prior Authorization from Both Sides
- Healthcare
February 18, 2025
Breaking Health Podcast
Payal Agrawal Divakaran with Jeffrey Wessler: Providing Virtual Cardiovascular Healthcare
- Healthcare
January 22, 2025
The VentureFizz Podcast
Graham Brooks – Partner, .406 Ventures (Episode 366)
- Data + AI
December 17, 2024
Breaking Health Podcast
Payal Agrawal Divakaran with Kate Condliffe: Accessible Maternity Care and the Future of Women’s Health
- Healthcare
October 22, 2024
Breaking Health Podcast
Payal Agrawal Divakaran with Kristina Saffran: Accessible Eating Disorder Treatments, Choosing Cofounders, More
- Healthcare
September 20, 2023
Venture Daily
Greg Dracon: Klaviyo NYSE Debut, DeepMind Predicts Gene Mutations, AI Security
- Data + AI
August 22, 2023
Venture Daily
Liam Donohue: Arm Files IPO, Corporate VCs Selling Assets, Boston is the New VC Hub
December 8, 2021
PointHealthTech Podcast
Payal Agrawal Divakaran: Why Payers Actually Have the Most Aligned Incentives to Change Healthcare
- Healthcare
March 15, 2021
The VentureFizz Podcast
Payal Agrawal Divakaran and Kathryn Taylor Reddy – .406 Ventures (Episode 210)
- Healthcare